This sanitary disc stack centrifuge is purpose-designed for high-density cell broth clarification, cell harvesting and biomass separation in biopharmaceutical upstream processes, perfectly suited for high-concentration mammalian cell cultures, microbial fermentation liquors and perfusion effluent capture scenarios.
The product-contact components adopt polished 316L stainless steel with compliant E&L verification, fully compatible with cGMP requirements and supporting automated CIP cleaning and SIP sterilization cycles. Optimized disc geometry and high centrifugal g-force deliver efficient solid-liquid separation even at extremely high cell densities, effectively separating intact host cells from supernatant containing target proteins, mAbs, viral vectors and recombinant products, while minimizing cell lysis and product leakage.
Equipped with automatic sludge discharge, continuous feeding and stable flow rate control, the unit enables uninterrupted long-run harvesting for commercial-scale biomanufacturing. Integrated process monitoring sensors and safety interlocks ensure stable running parameters, complete data recording and audit trails for regulatory filing. It seamlessly connects inline with bioreactor outlet pipelines, eliminating intermediate transfer risks and greatly improving downstream clarification efficiency and overall process yield, serving as a core solid-liquid separation workstation for large-volume biologic production lines.
