Specifically engineered for cell broth clarification, cell retention and supernatant collection in bioreactor harvesting workflows, this continuous flow centrifuge delivers high-throughput, uninterrupted solid-liquid separation tailored to mammalian cell cultures, microbial fermentation liquids and viral vector harvest streams.
Running under continuous feeding and continuous discharging mode, it avoids batch-wise loading/unloading downtime that plagues conventional batch centrifuges. Optimised low-shear rotor geometry effectively protects fragile therapeutic cells and secreted target proteins from excessive mechanical damage, securing high product viability and recovery yield. Fully closed sanitary flow path prevents external contamination, perfectly aligning with cGMP production requirements for monoclonal antibodies, recombinant proteins and advanced therapy raw material capture.
The integrated automated control system monitors rotational speed, feed flow rate, backpressure and separation efficiency in real time, enabling stable long-run operation matching perfusion bioreactor continuous manufacturing lines. Sanitary 316L stainless steel wetted parts support complete CIP/SIP cycles, with full data recording, audit trail and electronic signature functions complying with 21 CFR Part 11. Compact skid-mounted layout simplifies line integration and facility layout planning, drastically reducing harvest processing time, lowering labour costs and decreasing subsequent downstream purification load.
