The downstream chromatography system serves as the core equipment for the downstream purification process in biopharmaceuticals, including monoclonal antibodies, recombinant proteins, vaccines, CGT cell therapy and other products. It is mainly applied to the separation, purification, concentration and impurity removal after the harvesting of biological fermentation broth and cell culture fluid.
Adopting multiple chromatographic modes such as affinity chromatography, ion exchange chromatography, hydrophobic interaction chromatography and gel filtration chromatography, it can remove host cell proteins, nucleic acids, endotoxins, aggregates and impurity isomers. The system purifies target proteins and bioactive substances to meet pharmacopoeia and preparation standards, and is widely used in laboratory process development, pilot scale-up and commercial production.
