This continuous-flow industrial centrifuge is purpose-built for primary clarification of cell culture broth and fermentation harvest liquor in biopharmaceutical production, widely applied to remove whole cells, cell debris, flocculated particles and insoluble impurities ahead of depth filtration and chromatography purification steps for mAbs, recombinant proteins, plasmid DNA, viral vectors and vaccines.
Product contact flow paths adopt electropolished sanitary stainless steel, optimized hygienic flow channel layout without dead pockets, compatible with automated CIP cleaning and SIP sterilization, fully compliant with cGMP and ASME BPE bioprocess standards. Relying on high-speed centrifugal sedimentation, the equipment achieves continuous feeding, solid sludge automatic discharging and clarified supernatant continuous outflow simultaneously, enabling non-stop long-cycle stable operation for large-volume harvest material treatment.
Adjustable rotating speed, differential speed and feed flow rate allow flexible optimization of separation efficiency, effectively reducing solid load for subsequent filter trains and extending filter service life to cut consumable costs drastically. Integrated online vibration, temperature and torque monitoring plus overload interlock protection guarantee safe unattended running.
The matched automation system records full-process operating parameters, generates complete electronic batch records and audit trails to meet global data integrity requirements for regulatory audits and product registration. Skid-mounted integrated structure passes full FAT testing before delivery, supports seamless inline docking with upstream bioreactors and downstream buffer preparation & purification skids, forming a fully closed bioprocess workflow.
Compared with batch centrifugation and traditional filter press clarification, it features large single-line throughput, compact footprint, low labor reliance and easy process scale-up, serving as the core primary separation equipment for modern large-scale continuous biomanufacturing facilities.
