This hygienic disc stack centrifuge is specially engineered for solid-liquid separation and cell debris clearance in biopharmaceutical GMP-compliant production workshops, widely deployed post bioreactor harvest to remove broken cells, insoluble cell fragments, host cell particles and other suspended impurities from fermentation supernatant and cell culture fluid.
All product-contact components are fabricated from electropolished 316L stainless steel, fully passing E&L extractables and leachables verification. The equipment supports fully automated CIP cleaning and SIP sterilization cycles, eliminating cross-contamination risks and fully meeting cGMP hygiene and process control standards for biologic drug manufacturing. Optimized separation geometry delivers high centrifugal force, efficiently sedimenting heavy cell debris while gently discharging clarified supernatant containing target antibodies, recombinant proteins or viral particles, with controlled low shear to avoid product denaturation.
Equipped with automatic intermittent sludge discharge, stable continuous feeding flow control and full-process real-time parameter monitoring, the centrifuge enables long-term unattended continuous operation. Complete running logs and audit trails are automatically generated to satisfy data integrity requirements for regulatory inspections and filing. Featuring compact floor layout and seamless inline pipeline docking with downstream depth filtration and purification units, it acts as the core primary clarification workstation for pilot and commercial biomanufacturing lines.
