News I Sino Bioengineering

In the rapidly evolving landscape of biopharmaceutical manufacturing, upstream cell culture productivity has become the core bottleneck restricting the industrialization of monoclona……

Bioreactor scale-up is the core link from laboratory scale cultivation to industrial production in biopharmaceuticals, microbial fermentation, and cell therapy manufacturing. However……

Vaccines are the most cost-effective and efficient tools for the prevention and control of infectious diseases. Vaccination is a routine approach that induces protective immune resp……

African Swine Fever (ASF) is an acute, hemorrhagic and highly contagious disease caused by African Swine Fever Virus (ASFV), which infects domestic pigs and wild boars.……

Influenza vaccination is universally recognized as the most effective measure to prevent influenza infection and transmission. Commercially available influenza vaccines are mainly c……

With the rapid adoption of large-scale production processes in the biopharmaceutical industry, enterprises are increasingly pursuing economic benefits from scaled manufacturing, whi……

During the upstream processes of antibody production, cell culture media are prepared, transported and stored, while cell cultivation and harvest are also performed. In these stages……

Chinese Hamster Ovary (CHO) cells are the predominant host cells for producing therapeutic proteins such as monoclonal antibodies in biotechnology. The metabolism and regulation of ……

Driven by the rapid expansion and fierce competition in the biopharmaceutical market, optimization of manufacturing processes has become indispensable. Particularly in upstream biop……

Among various heterologous protein expression systems and culture modes, large-scale mammalian cell culture has long been the mainstream technology for the industrial production of ……

Mammalian cells are one of the most commonly used host cells in the biopharmaceutical industry, widely applied to the production of recombinant proteins and monoclonal antibodies. O……

Cell culture media supply cells with diverse nutrients and a microenvironment for cell growth and metabolism. They affect the activities of key intracellular enzymes associated with……

Vitamins are a class of trace organic compounds essential for humans and animals to maintain normal physiological functions. Despite being required in minute quantities, deficiency ……

Cell culture medium (CCM) components affect cell growth, as well as the production and critical quality attributes (CQAs) of monoclonal antibodies (mAbs) and recombinant proteins. I……

1 Development History of Serum-Free Media Driven by the expanding scale, higher efficiency and stricter biosafety requirements for animal cell culture in the biopharmaceutical ind……

Over 70% of recombinant macromolecular biotherapeutics are produced using Chinese Hamster Ovary (CHO) cells to date. This is primarily attributed to two key advantages: CHO cells ge……