News I Sino Bioengineering

Basic Principle of kLa The volumetric oxygen mass transfer coefficient kLa characterizes the oxygen transfer rate from gas phase to liquid phase, derived from the two-film theory. Th……

pH is a core process parameter throughout the entire fermentation cycle, and an intuitive indicator reflecting microbial growth status, metabolic activity and product synthesis tende……

1. Basic Overview of Inclusion Bodies 1.1 Definition of Inclusion Bodies Inclusion bodies (IBs) are intracellular macromolecular aggregates predominantly composed of proteins, distri……

Similar to protein production, plasmid DNA process development generally commences with small-scale exploratory studies. The procedures encompass construction and selection of approp……

1 Naked Plasmid DNA Delivery DNA exhibits far higher stability than RNA in biological systems. Direct intravenous injection of naked plasmid DNA yields robust transgene expression in……

Antibodies: Structure and Purification Challenges Antibodies (Immunoglobulins, Ig) are specific immune effector molecules generated by the body in response to antigen stimulation, se……

In the biopharmaceutical industry, whether for proteins, antibodies or emerging nucleic acid drugs, isolating a single active target component from crude mixtures constit……

Biotech pharmaceuticals occupy a substantial share of the global pharmaceutical market. Developed economies in Europe and America maintain a leading position in biopharmaceutical tec……

The clinical and commercial success of biopharmaceuticals has driven growing demand for larger-scale production capacity and greatly boosted upstream productivity, with current produ……

Centrifuges serve as the cornerstone of downstream biopharmaceutical manufacturing processes. Leveraging centrifugal force, they separate biological materials based on density to cla……

Disc stack centrifuges play a pivotal role in antibody purification. They separate cells from culture broth by centrifugal force and efficiently remove cell debris, delivering high-q……

Modern bioreactors are no longer simple cultivation vessels, but sophisticated engineered microecosystems. Designed to deliver optimal growth conditions for cells, they integrate eng……

Bioreactor technology is widely applied in cell-culture-based viral vaccine manufacturing. Especially during the COVID-19 pandemic, its advancement and application enabled efficient ……

A bioreactor is a device that conducts biochemical reactions in vitro by utilizing the biological functions of enzymes or organisms such as microorganisms. It creates an optimized ph……

1. Recombinant Protein Expression Recombinant protein expression aims to produce proteins with desirable solubility, folded conformation and biological activity using appropriate hos……

Recombinant proteins expressed in the form of bacterial inclusion bodies (IBs) have attracted substantial attention across industrial and medical biotechnology applications. Elucidat……