News I Sino Bioengineering

Instead of the huge, 10-ton, or even higher, annual production scale facilities for one single biopharmaceutical product, it seems more likely that many current and most future facil……

A significant issue in complying with cGMP regulations is the decision that the designer needs to make concerning the balance between physical facility solutions and procedural solut……

Segregation practices form the fundamental design strategy for the prevention of cross- contamination and protection of quality of the final bulk and intermediate products throughout……

Once the production capacity of the facility is determined, the overarching boundaries and constraints of the facility design are fixed. Regardless of the differing variables effecti……

The decision to design and build a new facility or expand an existing one almost always comes down to the business drivers of additional revenue and market share. For the biopharmace……

The first biopharmaceutical facilities for large-scale cultivation of recombinant micro-organisms were designed and commissioned decades ago . The relatively meager competitive lands……

During process scale-up, scale-independent variables including temperature, pH, dissolved oxygen setpoint and feeding strategy can be readily maintained stably. Nevertheless, scale-r……

Monoclonal antibodies (mAbs) are predominantly produced using Chinese hamster ovary (CHO) cells in large-scale bioreactors. Process development commences at small scales including sh……

In modern biopharmaceuticals, fermentation serves as a cornerstone for manufacturing diverse therapeutic products owing to its versatility and high efficiency. It enables large-scale……

Intelligentization and scale-up simulation of bioreactors serve as pivotal breakthrough points to overcome core bottlenecks in the industrialization of biomanufacturing. Essentially,……

Monoclonal antibodies (mAbs), other recombinant proteins and viral vectors have emerged as major pharmaceutical products. Their manufacturing predominantly relies on mammalian cell c……

Advancements in technology and deeper insights into biological process mechanisms enable large-scale production of high-purity biomolecules. Fermentation is currently app……

1. Advantages and Market Status of High-Concentration Protein Preparations With advances in biomedical technology and evolving market demands, high-concentration protein preparation……

Virus-like particles (VLPs) are self-assembled, non-replicative, non-pathogenic and highly organized supramolecular nanoparticles spontaneously formed by one or more viral capsid pro……

1. Definition of Inclusion Bodies Inclusion bodies (IBs) are high-density, insoluble protein granules encapsulated by membranes, formed during high-level heterologous gene expression……

The measurement and control system acts as the sensory organ and brain of the fermentation process. It collects real-time data, performs computational processing and clos……