Insight I Sino Bioengineering

Monoclonal antibodies (mAbs), other recombinant proteins and viral vectors have emerged as major pharmaceutical products. Their manufacturing predominantly relies on mammalian cell c……

Advancements in technology and deeper insights into biological process mechanisms enable large-scale production of high-purity biomolecules. Fermentation is currently app……

1. Advantages and Market Status of High-Concentration Protein Preparations With advances in biomedical technology and evolving market demands, high-concentration protein preparation……

Virus-like particles (VLPs) are self-assembled, non-replicative, non-pathogenic and highly organized supramolecular nanoparticles spontaneously formed by one or more viral capsid pro……

1. Definition of Inclusion Bodies Inclusion bodies (IBs) are high-density, insoluble protein granules encapsulated by membranes, formed during high-level heterologous gene expression……

The measurement and control system acts as the sensory organ and brain of the fermentation process. It collects real-time data, performs computational processing and clos……

Basic Principle of kLa The volumetric oxygen mass transfer coefficient kLa characterizes the oxygen transfer rate from gas phase to liquid phase, derived from the two-film theory. Th……

pH is a core process parameter throughout the entire fermentation cycle, and an intuitive indicator reflecting microbial growth status, metabolic activity and product synthesis tende……

1. Basic Overview of Inclusion Bodies 1.1 Definition of Inclusion Bodies Inclusion bodies (IBs) are intracellular macromolecular aggregates predominantly composed of proteins, distri……

Similar to protein production, plasmid DNA process development generally commences with small-scale exploratory studies. The procedures encompass construction and selection of approp……

1 Naked Plasmid DNA Delivery DNA exhibits far higher stability than RNA in biological systems. Direct intravenous injection of naked plasmid DNA yields robust transgene expression in……

Antibodies: Structure and Purification Challenges Antibodies (Immunoglobulins, Ig) are specific immune effector molecules generated by the body in response to antigen stimulation, se……

In the biopharmaceutical industry, whether for proteins, antibodies or emerging nucleic acid drugs, isolating a single active target component from crude mixtures constit……

Biotech pharmaceuticals occupy a substantial share of the global pharmaceutical market. Developed economies in Europe and America maintain a leading position in biopharmaceutical tec……

The clinical and commercial success of biopharmaceuticals has driven growing demand for larger-scale production capacity and greatly boosted upstream productivity, with current produ……

Centrifuges serve as the cornerstone of downstream biopharmaceutical manufacturing processes. Leveraging centrifugal force, they separate biological materials based on density to cla……