Insight I Sino Bioengineering

In the design and operation of bioreactors, hydrodynamic effects are consistently critical factors. Depending on the application area, their impacts can be divided into two categorie……

Over the past three decades, significant progress has been made in the production of therapeutic proteins in the biopharmaceutical industry, driving sustained growth in the market. I……

In recent years, the application of microbial cell factories in the biosynthesis of natural products has gradually become an important direction in biomanufacturing. Compared with tr……

HEK293 cells were originally isolated by Alex Van der Eb in the 1970s and subsequently transformed by Frank Graham using sheared fragments of adenovirus type 5 (Ad5) DNA. Owing to th……

Perfusion technology is widely applied in bioengineering, chemical engineering and other fields. The key fundamentals are introduced in detail as follows. Necessity of Perfusion Pain……

With the widespread adoption of precision medicine, an increasing number of therapeutic biologics such as bispecific antibodies, antibody-drug conjugates (ADCs), and CAR-T cell thera……

Suspension culture has been successfully validated for monoclonal antibody production using CHO cells as the optimal strategy to boost product titers and meet large-scale commercial ……

Recombinant vaccines are manufactured using recombinant DNA technology, which involves inserting DNA encoding antigens that stimulate an immune response into bacterial or mammalian c……

Although biopharmaceuticals offer high potency and target specificity, the efficient production of therapeutic proteins still faces multiple challenges. These include discovering new……

Vaccination is a critical component of public health policy and has proven to be a cost-effective strategy in protecting human and animal populations. However, traditional classical ……

With the rapid development of monoclonal antibody (mAb) and antibody-drug conjugate (ADC) pharmaceuticals, mammalian cell culture processes are continuously updated and optimized. Th……

mRNA is an important intracellular molecule that carries genetic information transcribed from DNA and directs protein synthesis. In biotechnology and medical fields, especially vacci……

The production of viruses or virus-like particles on an industrial scale using cell culture is a necessary prerequisite for gene therapy and the treatment of tumors with oncolytic vi……

In the biotechnology, biopharmaceutical, bioenergy, food, and feed industries, the efficient recovery of intracellular compounds is a critical step throughout R&D and large-scale……

Against the backdrop of the rapid development of the global biopharmaceutical industry, innovative therapies are entering clinical practice and the market at an unprecedented pace. F……

Influenza is an acute respiratory infectious disease caused by influenza viruses, infecting approximately 1 billion people globally each year, including 3–5 million severe cases and ……