Insight I Sino Bioengineering

Particle size stands as a decisive critical parameter throughout the delivery journey of mRNA-LNP therapeutics. Unlike mRNA molecules that carry genetic information or ionizable lip……

Driven by the rapid advancement of gene therapy, cell therapy and mRNA vaccines, the industry demand for plasmid DNA (pDNA) has surged. Developing robust plasmid manufacturing proce……

mRNA vaccines feature rapid production and superior process versatility, granting them unparalleled advantages in responding to public health emergencies. The successful deployment ……

In 2026, with the full implementation of EU GMP Annex 1 and the revised PDA Technical Report No. 26, the global sterile pharmaceutical manufacturing industry has undergone a compreh……

I. Design Philosophy of Cell Culture Media: Precision Bionics at the Microscale Inside living organisms, cells are sustained by the circulatory system, which delivers a constant t……

Cell culture medium serves as the fundamental substrate for in vitro cell growth. Its selection directly impacts cell status, experimental reproducibility and the credibility of res……

Overview Cell culture media are artificially formulated solutions that simulate the in vivo physiological environment of cells, supplying essential nutrients to sustain cell survival……

In industries including biotechnology, biopharmaceuticals, bioenergy, food and feed production, efficient recovery of intracellular compounds is a core link running through R&D ……

Fluid management is a sophisticated and highly precise core process in modern biopharmaceutical manufacturing. Ranging from medium preparation and fed-batch control in upstream cell……

Centrifugation With the advent of low-shear centrifuges, the use of continuous disk-stack centrifugation coupled with depth filtration became the industry-preferred method for harves……

Monoclonal antibodies (mAbs) are among the fastest-growing therapeutics and are being developed for a broad range of indications, from cancer to infectious diseases to cardiovascular……

Many factors influence the choice of expression system for production of recombinant proteins. These include the complexity of the target protein, the intended use of the product, an……

Continuous perfusion cell culture has been well established for many years in the production of biologics. In the past, this production mode was most desirable for labile products th……

Continuous and semicontinuous processes have been practiced in many industries for decades. Prime examples are steel, paper, and automobile production. These industries are all very ……

Process intensification, as defined here, is the desire to improve productivity (grams/L/h or grams/gram resin-hr or plant productivity in grams/plant-h). Intensification of a produc……

Cleaning validation is an area that demands considerable attention and often leads to negative comments during regulatory inspections. It has been suggested that for biotech products……