Insight I Sino Bioengineering

Among various heterologous protein expression systems and culture modes, large-scale mammalian cell culture has long been the mainstream technology for the industrial production of ……

Mammalian cells are one of the most commonly used host cells in the biopharmaceutical industry, widely applied to the production of recombinant proteins and monoclonal antibodies. O……

Cell culture media supply cells with diverse nutrients and a microenvironment for cell growth and metabolism. They affect the activities of key intracellular enzymes associated with……

Vitamins are a class of trace organic compounds essential for humans and animals to maintain normal physiological functions. Despite being required in minute quantities, deficiency ……

Cell culture medium (CCM) components affect cell growth, as well as the production and critical quality attributes (CQAs) of monoclonal antibodies (mAbs) and recombinant proteins. I……

1 Development History of Serum-Free Media Driven by the expanding scale, higher efficiency and stricter biosafety requirements for animal cell culture in the biopharmaceutical ind……

Over 70% of recombinant macromolecular biotherapeutics are produced using Chinese Hamster Ovary (CHO) cells to date. This is primarily attributed to two key advantages: CHO cells ge……

Since the early 21st century, the global biopharmaceutical industry has experienced rapid growth. By December 2022, over 100 chimeric, humanized, and fully human monoclonal antibody……

A high-concentration formulation refers to a dosage form with a high content of active pharmaceutical ingredients (API) per unit volume of solution. This formulation is primarily de……

In the manufacturing of biopharmaceuticals and chemical drugs, the risks posed by Extractables & Leachables (E&L) from single-use plastic components directly impact drug qua……

Over the past decade, the biopharmaceutical manufacturing industry has shown growing interest in bioprocess intensification. Nevertheless, its development pace has fallen short of t……

During the transition from laboratory-scale bench trials to industrial production in fermentation industries, fermenter scale-up is a pivotal factor determining production efficienc……

In the modern biopharmaceutical industry, fermentation stands as a cornerstone for manufacturing diverse therapeutic products due to its versatility and high efficiency. It enables ……

Monoclonal antibodies, other recombinant proteins, viral vectors and other biotherapeutics have become a major class of pharmaceuticals, whose production predominantly relies on mam……

Bioreactor scale-up constitutes the pivotal transition for biopharmaceutical products moving from lab-scale development to commercial manufacturing. Its core dilemma lies in preserv……

In bioreactor design and operation, hydrodynamic effects constitute a core governing factor. Based on application scenarios, their impacts fall into two distinct categories. The fir……