Insight I Sino bioengineering

As a vital component of modern pharmaceutical industry, biological products play an essential role in disease treatment and public health protection. The biological product industry ……

Bispecific antibodies (bsAbs) represent a promising class of biotherapeutics. Accordingly, downstream processing of such antibodies is critical to ensuring the production of high-pur……

In the biopharmaceutical industry, Chinese Hamster Ovary (CHO) cells have emerged as the gold-standard expression system for recombinant protein production. The conventional fed-batc……

Since the first monoclonal antibody drug was approved in 1986, the research and development of antibody drugs have flourished. Up to now, antibody drugs have become an important part……

With the continuous advancement of biomedical technologies, multispecific antibodies (MSAs) have demonstrated enormous potential in the therapeutic field. Capable of targeting multip……

Virus-like Particles (VLPs) are unique biomaterials that structurally mimic the morphology and configuration of native viruses, yet they contain no viral genetic material such as DNA……

In the design and operation of bioreactors, hydrodynamic effects are consistently critical factors. Depending on the application area, their impacts can be divided into two categorie……

Over the past three decades, significant progress has been made in the production of therapeutic proteins in the biopharmaceutical industry, driving sustained growth in the market. I……

In recent years, the application of microbial cell factories in the biosynthesis of natural products has gradually become an important direction in biomanufacturing. Compared with tr……

HEK293 cells were originally isolated by Alex Van der Eb in the 1970s and subsequently transformed by Frank Graham using sheared fragments of adenovirus type 5 (Ad5) DNA. Owing to th……

Perfusion technology is widely applied in bioengineering, chemical engineering and other fields. The key fundamentals are introduced in detail as follows. Necessity of Perfusion Pain……

With the widespread adoption of precision medicine, an increasing number of therapeutic biologics such as bispecific antibodies, antibody-drug conjugates (ADCs), and CAR-T cell thera……

Suspension culture has been successfully validated for monoclonal antibody production using CHO cells as the optimal strategy to boost product titers and meet large-scale commercial ……

Recombinant vaccines are manufactured using recombinant DNA technology, which involves inserting DNA encoding antigens that stimulate an immune response into bacterial or mammalian c……

Although biopharmaceuticals offer high potency and target specificity, the efficient production of therapeutic proteins still faces multiple challenges. These include discovering new……

Vaccination is a critical component of public health policy and has proven to be a cost-effective strategy in protecting human and animal populations. However, traditional classical ……