Insight I Sino bioengineering

With the rapid development of monoclonal antibody (mAb) and antibody-drug conjugate (ADC) pharmaceuticals, mammalian cell culture processes are continuously updated and optimized. Th……

mRNA is an important intracellular molecule that carries genetic information transcribed from DNA and directs protein synthesis. In biotechnology and medical fields, especially vacci……

The production of viruses or virus-like particles on an industrial scale using cell culture is a necessary prerequisite for gene therapy and the treatment of tumors with oncolytic vi……

In the biotechnology, biopharmaceutical, bioenergy, food, and feed industries, the efficient recovery of intracellular compounds is a critical step throughout R&D and large-scale……

Against the backdrop of the rapid development of the global biopharmaceutical industry, innovative therapies are entering clinical practice and the market at an unprecedented pace. F……

Influenza is an acute respiratory infectious disease caused by influenza viruses, infecting approximately 1 billion people globally each year, including 3–5 million severe cases and ……

Recombinant proteins play a pivotal role in modern biopharmaceuticals (including therapeutic antibodies, enzymes, vaccines, and cytokines), diagnostic reagents, and industrial enzyme……

Inside the clean workshops of biopharmaceutical manufacturing, rows of cylindrical Single-Use Bioreactors (SUBs) operate silently. Unlike traditional stainless steel bioreactors, the……

As an important class of therapeutic molecules in modern biopharmaceuticals, fusion proteins exhibit unique therapeutic potential by combining multiple distinct functional protein do……

In biopharmaceutical and biotechnological fields, Tangential Flow Filtration (TFF), also referred to as Cross Flow Filtration (CFF), has emerged as a core unit operation in downstrea……

Introduction to Collagen Collagen is a general term for a class of biological macromolecular proteins. As the most abundant structural protein in animals, it accounts for 25%–35% of ……

Immunoglobulin M (IgM), the largest and structurally most complex member of the antibody family, has recently returned to the spotlight of biopharmaceutical R&D. Nevertheless, th……

In the field of cell and gene therapy (CGT), high-quality plasmid DNA (pDNA) serves as an indispensable foundational raw material. Whether applied in viral vector manufacturing, in v……

Against the backdrop of the rapid commercialization of cell and gene therapy, lentiviral vectors (LVVs)—as critical gene delivery tools—are evolving from laboratory-scale methods to ……

In the broader landscape of biopharmaceutical manufacturing, downstream processing is responsible for extracting and purifying target biomolecules from complex cell culture broth. If……

Driven by the rapid advancement of gene therapy and cell therapy in recent years, lentiviral vectors have emerged as core tools for diverse therapeutic strategies owing to their capa……