Insight I Sino Bioengineering

mRNA-lipid nanoparticle (mRNA-LNP) technology stands as a milestone in modern vaccine development, represented by BNT162b2 (Comirnaty) co-developed by BioNTech and Pfizer, as well a……

Antibody-drug conjugates (ADCs) have garnered tremendous attention in oncology therapeutics owing to their precise targeted cytotoxicity, sustaining robust market momentum. The purif……

Sterile pharmaceutical products require hermetically sealed container closure systems. Effective sealing prevents product contamination, serving as the fundamental safeguard for pat……

Antibodies: Structural Features and Purification Challenges Antibodies (Abs) are specific immunoglobulins generated by the immune system upon antigen stimulation, serving as pivot……

Escherichia coli is one of the longest-established and most widely used host systems for the expression of recombinant therapeutic proteins. To date, over 25% of recombinant biophar……

Sterility is one of the most critical quality attributes for parenteral preparations, injectables, biopharmaceuticals and numerous other pharmaceutical products. Sterilizing filtrat……

Hyaluronic acid (HA) is a naturally occurring biopolymer widely found in nature. As a linear, non-sulfated glycosaminoglycan, it is primarily composed of N-acetylglucosamine and glu……

1. Human Intravenous Immunoglobulin (IVIG) Human Intravenous Immunoglobulin (IVIG) plays a vital role in humoral immunity. It recognizes and neutralizes pathogens or toxins, activ……

Streptococcus pneumoniae comprises more than 100 serotypes and is a major pathogenic bacterium responsible for severe infections such as pneumonia, meningitis and bacteremia. It po……

Bispecific and trispecific antibodies feature intricate structures and poor conformational stability. Their downstream purification processes must shift from the conventional platfo……

Influenza remains a major threat to global public health, causing substantial morbidity and mortality worldwide each year. Vaccination is the core intervention to prevent influenza a……

Botulinum neurotoxins (BoNTs) are potent neurotoxic proteins produced by Clostridium botulinum, ranking among the most toxic known biological substances. Administered via local inj……

In biopharmaceutical production, raw materials are widely recognized as a critical source of variability affecting process stability and product consistency, among which cell cultur……

1. Overview of Plant-Derived Recombinant Collagen As a high-profile biomanufacturing product in recent years, plant-derived recombinant collagen has witnessed robust industry grow……

As a next-generation therapeutic modality, mRNA has demonstrated tremendous potential in tumor immunotherapy and vaccine development. However, the in vitro transcription (IVT) stag……

In March 2026, Foot-and-Mouth Disease Virus Southern African Territories 1 (FMDV SAT1) was introduced into Xinjiang, Gansu and other regions of China from overseas, drawing nationwi……